Chappell LT, Stahl JP
87% of all studied patients demonstrated significant clinical improvement by objective measurement. The meta-analysis revealed a statistical correlation coefficient of 0.88 between EDTA therapy and improved cardiovascular function — indicating a high positive relationship across all included studies.
87% of all studied patients demonstrated significant clinical improvement by objective measurement. The meta-analysis revealed a statistical correlation coefficient of 0.88 between EDTA therapy and improved cardiovascular function.
Bottom line — This early meta-analysis pooled cardiovascular outcomes across 19 studies and 22,765 patients, reporting that 87% showed clinical improvement following EDTA chelation, with a strong statistical correlation (r = 0.88) between treatment and improvement. The meta-analysis predates modern RCT standards and consists primarily of observational and pre-RCT data — a useful historical signal that motivated the NIH-funded TACT trial, but not equivalent in rigor to the randomized evidence that followed.